2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), Uppsalalaan 8 Nature 374: 70-74 (1995), 3)              Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H.Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion. The Hubrecht Institute is one of the fifteen outstanding national research institutes of the Royal Netherlands Academy of Arts and Sciences (KNAW). A springboard for senior group leaders. Nature 425: 633-637 (2003), 16)           Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J., Clevers, H.C. 2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht Daughters of the small intestinal stem cells, the Paneth cells, serve as crypt niche cells by providing Wnt, Notch and EGF signals (30). 2016    Swammerdam medal, Amsterdam Royal Netherlands Academy of Arts and Sciences (KNAW), Princess Máxima Center for pediatric oncology (PMC), European Molecular Biology Laboratory (EMBL), Celebrating 100 years of Developmental Biology at the Hubrecht Institute, Hubrecht Institute Centennial – From embryos to stem cells, On the shoulders of Hubrecht: From embryos to stem cells. 54)           Roerink S.F., Sasaki N., Lee-Six H., Young M.D., Alexandrov L.B., Behjati S., Mitchell T.J., Grossmann S., Lightfoot H., Egan D.A., Pronk A., Smakman N., van Gorp J., Anderson E., Gamble S.J., Alder C., van de Wetering M., Campbell P.J., Stratton M.R., Clevers H. Intra-tumour diversification in colorectal cancer at the single-cell level. Research groups. In addition to external training, internal training is organized for all employees. Nature 476: 293-297 (2011), 34)           Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex. 2012 – 2015      Member of the Board of the American Association of Cancer Research He lived at the Janskerkhof in Utrecht, an official residence that later also contained the Anatomy/Embryology Laboratory and the Anatomy Museum of Utrecht University. 2017    Princess Takamatsu Award of Merit, Tokyo Here, several important advances in developmental biology were made, including the pioneering work of Pieter Nieuwkoop, after whom the area of an embryo called the “Nieuwkoop center” is named. 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna Hans Clevers (Hubrecht Institute) states: "These organoids contain the cells of the human intestinal lining, making them a compelling model to investigate infection by SARS-CoV-2." ); a.vanoudenaarden{at}hubrecht.eu (A.v.O.) The related Lgr6 marks multipotent skin stem cells (29). Science 327: 1385-1389 (2010), 30)           Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Research at the Hubrecht Institute focuses on developmental biology and stem cells at the organismal, cellular, and molecular level. For these studies, we designed the widely used pTOPFLASH Wnt reporters. Cell Stem Cell 6: 25-36 (2010), 29)           Snippert, H.J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J.H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R.G., Stange, D.E., Toftgård, R., Clevers H.  Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. This is reflected by our broad introduction program, yearly evaluation meetings and regular drinks and outings to improve integration, collaboration and relaxation. Science  358: 234-238 (2017). The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. During the last five years, the Hubrecht Institute has been very successful in attracting young talented group leaders who started a tenure track at our institute. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal … Upon Wnt signaling, ß-catenin binds and activates nuclear TCFs by providing a trans-activation domain. 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Cell 143:134-44 (2010), 33)           de Lau, W., Barker, N., Low, T.Y., Koo, B.K., Li, V.S., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P.J., van de Wetering, M., Stange, D.E., van Es, J., Guardavaccaro, D., Schasfoort, R.B., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A.J., Clevers, H. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. The Clevers group studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. 2014 – 2015      TEFAF Oncology Chair, Maastricht A center for interdisciplinary biomedical research. 2 Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. Science 275: 1784-1787 (1997), 6)              Morin, P.J., Sparks, A., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. 2020 – present  Member of the Board of Genentech, South San Francisco Cell 172:373-386 (2018). The impact score places the Hubrecht also as one of the premier biology research institutes world-wide. 2015                     Dr. Paul Janssen Award, Bruxelles The direct cloning of multiple individual cells from primary tumors allows molecular and functional analysis of tumor heterogeneity with an unprecedented resolution (54). Since 2008, the Hubrecht Institute is affiliated with University Medical Center Utrecht (UMC Utrecht), which belongs to the largest public healthcare institutions in the Netherlands and is an internationally leading healthcare provider, medical school and research institute that is exciting for its people, attractive to talent and embodies a culture of teamwork, innovation, sustainability and a competitive spirit. The Hubrecht Institute further expanded in 2015 with a new laboratory building that was attached to the old building. Life Sciences and Health is one of the main themes of research and education. 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam Nature 435: 959-963 (2005), 21)           Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., van de Born, M., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S., Clevers, H. EphB activity suppresses colorectal cancer progression. 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. Maurice, M.M. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. 3584 CT Utrecht Research; Strategy; Organization; Location; Our partners; History; Open access; Working at the Hubrecht Institute; Contact. The Hubrecht Institute was named after Ambrosius Arnold Willem Hubrecht (1853-1915), professor of Zoology in the Faculty of Medicine of Utrecht University. 3 Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Research at the Hubrecht Institute has direct implications for translational and clinical applications. More than 10 years after the cultivation of the first organoid – at the Hubrecht Institute by Toshiro Sato in the group headed by Hans Clevers – the path to commercial applications is open. Contact. We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures. Have a look at our vacancies. A magnet for young talent. View ORCID Profile Hans Clevers 2, †, ‡ 1 Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands. Find 152 researchers working at Hubrecht Institute | Utrecht, Netherlands | One of the main goals of the Hubrecht Institute is to build an interdisciplinary research institute that can tackle the most important problems in modern biology and medicine. Sort. Cell 111: 251-263 (2002), 15)           Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., Clevers, H. The Wnt/beta-catenin pathway regulates cardiac valve formation. 2017 – present  Shaw Prize, Hong Kong 2012    The Heineken Prize for Medicine Nature 457: 608-611 (2009), 26)           van der Flier, L.G., van Gijn, M.E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D.E.,  Begthel, H., van den Born, M., Guryev, V., Oving, I.,  van Es, J.H., Barker, N., Peters, P.J., van de Wetering, M. and Clevers, H. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate. 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. Nature 380: 711-714 (1996), 4)              Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. Research at the Hubrecht Institute is pioneering in developmental and stem cell biology. Marie-José Goumans. 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco The board of directors, consisting of Prof. Alexander van Oudenaarden (director) and Prof. Jeroen den Hertog (managing director) maintains a flat organizational structure with tenure track positions for junior group leaders. Hubrecht Organoid Technology (HUB) was founded by the Hubrecht Institute, the University Medical Center Utrecht, and the Royal Netherlands Academy of Arts and Sciences (KNAW). The institute currently ranks as one of the top institutes worldwide in the field. 2002 – present  Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht It promotes quality in science and scholarship and strives to ensure that Dutch scholars and scientists contribute to cultural, social and economic progress. Johannes Carolus (Hans) Clevers is Principal Investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research (KNAW) and the Princess Máxima Center for Pediatric Oncology, Professor of Molecular Genetics at the UMC Utrecht and Utrecht University, and Oncode Investigator. Utrecht Life Sciences is a platform that supports collaboration and innovation. Dr. Clevers is a Professor of Molecular Genetics at Hubrecht Institute, Utrecht, The Netherlands. So says Robert Vries, who has been working since 2013 to make HUB (Hubrecht Organoid Technology) the … Related genes exist in genomes throughout the animal kingdom.We have shown in frogs (4), flies (7) and worms (11) that the TCF proteins constitute the effectors of the canonical Wnt pathway. The Princess Máxima Center has open her own new hospital and research building at the Utrecht Science Park in May 2018. At the start of their PhD, the PhD students draft a Training & Supervision Agreement (TSA) and during their PhD they have yearly meetings with their supervisory committee, which includes 2-3 independent researchers. Hans Clevers ‡ Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands. ↵ † Present address: … 9 Hubrecht Organoid Technology, Utrecht, The Netherlands. Dolf Weijers: roots of the future. Hans Clevers (Hubrecht Institute): "These organoids contain the cells of the human intestinal lining, making them a compelling model to investigate infection by SARS-CoV-2." Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or … floxed), Reporter) Gt(ROSA)26Sor: gene … 2002 – 2012      Director Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences As a patient-centered organization, its 11,000 employees are dedicated to prevent disease, improve healthcare, develop new treatment methods and refine existing ones, with quality and patient safety as cornerstones. 2019    Keio Medical Science Prize of the Keio University (Japan) These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and -probably- all other epithelial stem cell types of the mammalian body. Ushering in a new era of personalised medicine and drug development, Dutch molecular geneticist Hans Clevers and teams at the Hubrecht Institute and the University Medical Center (UMC) in Utrecht pioneered so-called "organoids". European Molecular Biology Laboratory (EMBL) 2001    Spinoza Award of the Netherlands Research Council (NWO) h.clevers@hubrecht.eu. 2015 – 2019      Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht Cell Stem Cell 13: 653-658 (2013), 44)           Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Cell 175:1591-1606 (2018), 56)           Gehart, H., van Es, J., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J.F., Rios, A., and Clevers, H. Identification of enteroendocrine regulators by real-time single-cell differentiation mapping 10:123-132 (1991), 2)              Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. Founded in 1974, the European Molecular Biology Laboratory (EMBL) is Europe’s flagship laboratory for the life sciences – an intergovernmental organization with more than 80 independent research groups covering the spectrum of molecular biology. Modeling development and disease with organoids, Sequential cancer mutations in cultured human intestinal stem cells, Visualization of the short-range Wnt gradient in the intestinal stem cell niche, Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients, Organoid models of human and mouse ductal pancreatic cancer, Long-term culture of genome-stable bipotent stem cells from adult human liver, Identification of multipotent luminal progenitor cells in human prostate organoid cultures, Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo imaging, Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients, Differentiated Troy+ chief cells act as ‘reserve’ stem cells to generate all lineages of stomach epithelium, The intestinal crypt, a prototype stem cell compartment, Growing self-organizing mini-guts from a single intestinal stem cells: mechanism and applications, In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration, Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand, DII (+) secretory progenitor cells revert to stem cells upon crypt damage, Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas, Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors, Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling, Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex, Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells, Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin, Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro, Single Lgr5 gut stem cells build crypt-villus structures in vitro without a mesenchymal niche, Transcription factor Achaete scute-like 2 (Ascl2) controls intestinal stem cell fate, Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer, Lgr5 marks cycling, yet long-lived, hair follicle stem cells, Identification of Stem Cells in Small Intestine and Colon by a Marker Gene LGR5, Wnt/ß-catenin signaling in development and disease, EphB activity suppresses colorectal cancer progression, Notch pathway/gamma-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells, Self-renewal and cancer of the gut: Two sides of a coin, De novo crypt formation and Juvenile Polyposis upon BMP inhibition, Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD, The Wnt/beta-catenin pathway regulates cardiac valve formation, Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB, The beta-catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells, Linking colorectal cancer to Wnt signaling, Distinct beta-catenins mediate adhesion and signalling functions in C. elegans, Synergy between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1, The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors, Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4, Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC -/- Colon Carcinoma, Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos, Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4, An HMG box containing T-cell factor required for thymocyte differentiation, Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL) based on shared institutional goals, scientific synergy and complementarity. Oncode includes 62 research groups of the Dutch University Medical Centers, the Hubrecht Institute and the Netherlands Cancer Institute. Cell 160: 324-338 (2015), 48)           van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R.,  van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients. Dolf Weijers. and Clevers, H. Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Snippert, H.J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J.H., Barker, N., van de Wetering, And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . Many of these positions are leadership positions, such as institute director or head of department. Hubrecht Institute - Utrecht. On average, one group leader annually moves on to a new position outside the Institute. Since 2008, the Hubrecht Institute is affiliated with University Medical Center Utrecht (UMC Utrecht), which belongs to the largest public healthcare institutions in the Netherlands and is an internationally leading healthcare provider, medical school and research institute that is exciting for its people, attractive to talent and embodies a culture of teamwork, innovation, sustainability and a competitive spirit. Nature 507: 362-365 (2014), 45)           Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. The Hubrecht aims to be a springboard for talent and offers its employees the opportunity for personal and professional development, through a wide variety of workshops and courses, including those organized by our mother organization the Royal Netherlands Academy of Arts and Sciences (KNAW). Genetic Background Generation; F?+F23 (2020-01-20 00:00:00) Gt(ROSA)26Sor tm1(CAG-Brainbow2.1)Cle. The Clevers group studies the biology of Wnt signaling in tissue turnover and in cancer. In 2007 the name was changed from Hubrecht Laboratory to Hubrecht Institute. Nature 556, 437-462 (2018). In a collaboration with the Cystic Fibrosis clinic in Utrecht, a functional assay was established for the CFTR channel using rectal organoids. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Cell 159:163-175 (2014), 46)           Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human liver. 2018    Academia Europaea Erasmus Medal, Barcelona, Spain Cell 176:1158-1173 (2019), 57)          Schutgens F., Rookmaaker, M.B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yousef Yengej, F., de Winter – de Groot, K.M., Artegiani, B., van Boxtel, R., Cuppen, R., Hendrickx, A.P.A., van den Heuvel – Eibrink, M.M., Heitzer, E., Lanz, H., Beekman, J., Murk, J., Masereeuw, R., Holstege, F., Drost, J., Verhaar, M.C., Clevers, H. Human Adult Kidney-derived Tubuloids as Personalized Disease Models in a Dish and on a Chip During the last five years this interdisciplinary approach strengthened significantly. Wnt signaling intimately interacts with the BMP and Notch cascades to drive proliferation and inhibit differentiation in intestinal crypts and adenomas (17, 20). Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. and Clevers, H.C. An HMG box containing T-cell factor required for thymocyte differentiation. Finally, organoids (as first described by Sasai for pluripotent stem cells and by us for adult stem cells) are rapidly gaining ground as research tools in a wide range of scientific disciplies including basic developmetal and cell biology, infectiology, toxicology and research on hereditary diseases and cancer. Cell 161: 933-945 (2015), 49)           Drost, J., van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Cell 88, 789-799 (1997), 8)              Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York Hans Clevers is professor of Molecular Genetics at Utrecht University and the UMC Utrecht, Principal Investigator at the Hubrecht Institute (KNAW) and the Princess Máxima Center for Pediatric Oncology and Oncode Investigator.. Royal Netherlands Academy of Arts and Sciences (KNAW) 2014 – present  Breakthrough Prize in Life Sciences, San Francisco 17 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands. This technology is based on the discovery of the LGR5 positive adult epithelial stem cell, first identified in the intestine by the group headed by Prof. Hans Clevers. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute, 1985 – 1989      Postdoctoral Fellow, Cox Terhorst Lab at the Dana-Farber Cancer Institute, Boston MA, USA, 1989 – 1991      Assistant Professor, Department of Clinical Immunology, University of Utrecht. They also represent the cells-of-origin of adenomas in the gut (25) and within adenomas Lgr5 stem cells act as adenoma stem cells (36). and Clevers, H. Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4. 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany Nature Cell Biology 14: 1099-1104 (2012), 38)           Boj, S,F., van Es, J.H.,Huch. 1991 – 2002      Professor and Chairman, Dept. Hans Clevers is professor of Molecular Genetics at Utrecht University and the UMC Utrecht, Principal Investigator at the Hubrecht Institute (KNAW) and the Princess Máxima Center for Pediatric Oncology and Oncode Investigator. The Princess Máxima Center has open her own new hospital and research building at the Utrecht Science Park in May 2018. 2016    The Ilse & Helmut Wachter award, Hamburg, Germany Publications 19. 2009               Member of the Academia Europaea In the UMC Utrecht, research is concentrated in six programs with each a limited number of disease targets. Nature 434: 843-850 (2005), 20)           Van Es, J.H., Van Gijn, M.E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D.J., Radtke, F., Clevers H. Notch pathway/γ-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells. People are our most valuable asset and we appreciate every employee for their contribution to the success of the institute. In 2016, the Hubrecht Institute celebrated its 100th anniversary. 9 Hubrecht Organoid Technology, Utrecht, The Netherlands. 2014    National Icon of the Netherlands UMC Utrecht At the beginning of the 1880s Hubrecht corresponded with Charles Darwin, who paved the way for the theory of evolution in his book “On the origin of species”. Hans Clevers is group leader at the Hubrecht Institute and the Princess Máxima Center for Pediatric Oncology, professor of Molecular Genetics at the UMC Utrecht and Utrecht University, and Oncode Investigator. Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. Nature 521: 43-47 (2015), 50)           Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. Based on these combined insights, we have established Lgr5/R-spondin-based culture systems that allow the outgrowth of single mouse or human Lgr5 stem cells into ever-expanding mini-guts (27, 31), mini-stomachs (28), colon cancer organoids (31, 48) liver organoids (39, 46), prostate organoids (45), breast cancer organoids (53), ovarian cancer organdies (58) and organoids representing human hepatocytes (55) and human kidney in health and disease (57). The Hubrecht Institute has a tight collaboration with the UU on multiple levels: there is a lot of scientific collaboration, several PI’s are appointed as professor at the UU, all Hubrecht PhD students participate in the Graduate School of Life Sciences and various Master students perform their internships at one of the Hubrecht groups. and Clevers, H. Van de Wetering, M., Cavallo, R., Dooijes, D., Van Beest, M., Van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. Morin, P.J., Sparks, A., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. Korinek, V, Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. 2016    Kazemi Award for Research Excellence in Bio-Medicine These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (31, 46, 53). Hubrecht Organoid Technology. Researchers from the UMC Utrecht work alongside researchers from the Hubrecht Institute in this new building. 2006 – 2008      President of the International Society of Differentiation (ISD) 220 were here. Oncode Institute is a virtual, independent research institute dedicated to outsmarting cancer and impacting lives. Wnt Intestine Organoid Adult stem cell. 3584 CT Utrecht He also serves as Director of the Princess Maxima Center for Pediatric Oncology. He also serves as Director of the Princess Maxima Center for Pediatric Oncology. Prof. Dr. James Sharpe, EMBL, Barcelona Prof. Dr. Nynke Dekker, Kavli Institute of Nanoscience, Delft Oncode Institute ↵ ‡ To whom correspondence should be addressed. and Clevers, H. Stange, D.E., Koo, B.K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A.,Kujalla, P., Bartfeld, S., Koster, J., Geahlen, J.H., Peters, P.J., van Es, J., van de Wetering, M., Mills, J.C., Clevers, H. Huch M., Dorell, C., Boj, S.F., van Es, J.H., van de Wetering, M., Li, V.S.W., Hamer, K., Sasaki, N., Finegold, M.J., Haft, A., Grompe, M., Clevers, H. Boj, S,F., van Es, J.H.,Huch. 2020 – present  University Professor at University Utrecht, 2000    Catharijne prize for medical research Cell 127 (3), 469-480, 2006. The Hubrecht Institute strongly supports open access of all scientific publications. of Immunology, Faculty of Medicine, 2002 – 2012      Director Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 2002 – 2020      Professor in Molecular Genetics at University Medical Center Utrecht, 2002 – present  Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht, 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam, 2014 – 2020      Chief Scientific Officer of HUB Organoids Technology, Utrecht, 2015 – 2019      Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht, 2015 – present  Principal Investigator at the Princess Máxima Center, Utrecht, 2000    Catharijne prize for medical research, 2001    Award from the European Society for Clinical Investigation, 2001    Spinoza Award of the Netherlands Research Council (NWO), 2004    Louis-Jeantet Prize for Medicine, Geneva, Switzerland, 2005    The Science and Society Prize, Amsterdam, 2005    The French honor of “Chevalier de la Legion d’Honneur”, 2005    Katharine Berkan Judd Award, New York, 2006    Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research, Jerusalem, 2008    Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam), 2008    Meyenburg Cancer Research Award, Germany, 2009    The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam, 2010    The United European Gastroenterology Federation (UEGF) Research Prize, 2011    The Ernst Jung Medical Award, Germany, 2012    Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, Paris, 2012    William Beaumont prize of the American Gastroenterology Association, 2012    Knight in the Order of the Netherlands’ Lion, 2013    The Breakthrough Prize in Life Sciences, 2013    International Dream Team (with Hans Bos) by Dutch Cancer Society (KWF), 2014    Massachusetts General Hospital Award in Cancer Research, 2014    TEFAF Oncology Chair 2014, Maastricht, 2014    Struyvenberg European Society for Clinical Investigation (ESCI) medal, 2015    ISSCR-McEwen Award for Innovation, 2016    The Academy Professor Prize of the Royal Netherlands Academy, 2016    Kazemi Award for Research Excellence in Bio-Medicine, 2016    The Körber European Science Prize, Germany, 2016    The Ilse & Helmut Wachter award, Hamburg, Germany, 2017    Princess Takamatsu Award of Merit, Tokyo, 2018    Großes Verdienstkreuz mit Stern, Germany, 2018    Academia Europaea Erasmus Medal, Barcelona, Spain, 2019    Citation Laureate, Web of Science Group, 2008 – 2015      Louis Jeantet Prize, Geneva, 2013 – 2015      Canada Gairdner Award, Toronto, 2014 – present  Breakthrough Prize in Life Sciences, San Francisco, 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy, 2015                     Dr. Paul Janssen Award, Bruxelles, 2017 – present  Francqui Prize, Bruxelles, 2017                     Kovalenko Medal, National Academy of Sciences Washington, 2002 – present  Central South University, Chang Sha, China, 2014 – 2015      TEFAF Oncology Chair, Maastricht, 2015 – 2016      Visiting professor, Weizmann Institute, Rehovoth, Israel, 2016 – present  Distinguished Visiting Professor, University of Hong Kong, 2015 – present  Visiting professor, University of Melbourne, Australia, 2019 – present  Honorary Director, Fudan Organoid Center, Fudan University, Shanghai, 2019 – present  Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999               Member European Molecular Biology Organisation (EMBO), 2000               Member of the Royal Netherlands Academy of Sciences (KNAW), 2009               Member of the Academia Europaea, 2012               Member of the American Academy of Arts and Sciences, 2012               Member of the Royal Netherlands Society of Sciences and Humanities, 2014               Member of the National Academy of Sciences of the USA, 2016               Member of the Academie des Sciences de I’Institut de France, 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany, 2019               Foreign Member of the Royal Society, London, United Kingdom, 2019               Honorary Fellow of the Royal Society of Edinburgh, Scotland, 2005 – 2015      Member Scientific Advisory Board of Swiss Institute for Experimental Cancer Research, Lausanne, 2006 – 2008      President of the International Society of Differentiation (ISD), 2007 – 2010      Member of the National Scientific Advisory Board NKI-AVL, Amsterdam, 2012 – 2015      Member of the Board of the American Association of Cancer Research, 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna, 2016 – 2020      Member of the Scientific Advisory Board of Kallyope, New York, 2016 – present  Member of the Scientific Advisory Board of the Francis Crick Institute, London, 2016 – present  Member of the Scientific Advisory Board of Decibel Therapeutics, Boston, 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco, 2017 – 2018      President of the International Society for Stem Cell Research (ISSCR), 2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht, 2018 – present  Scientific advisor Life Science Partners, Amsterdam, 2019 – present  Non-executive member of the Board of Directors of Roche Holding Ltd, Basel, 2020 – present  Member of the Board of Directors of Genentech, South San Francisco, 2020 – present  Member of the Board of Genentech, South San Francisco, 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York, 2020 – present  Chair of the Scientific Advisory Board DImed Inc., Shanghai, 2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), SARS-CoV-2 productively Infects Human Gut Enterocytes, Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli, An organoid platform for ovarian cancer captures intra- and inter-patient heterogeneity, Tubuloids derived from human adult kidney and urine for personalized disease modeling, Identification of enteroendocrine regulators by real-time single-cell differentiation mapping, Long-term expansion of functional mouse and human hepatocytes as 3D organoids, Intra-tumour diversification in colorectal cancer at the single-cell level. 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